Sexual dysfunction The SSRIs as a class produce a variety of sexual side effects, including anorgasmia, decreased libido, impotence, and delayed ejaculation.
Analysis of the clinical trials suggests that fluvoxamine and fluoxetine are less likely to produce sexual side effects than paroxetine and sertraline.
SSRIs seem to relieve symptoms of depression by blocking the reabsorption (reuptake) of serotonin by certain nerve cells in the brain.
This leaves more serotonin available, which enhances neurotransmission and improves mood.
This leads to differences among the SSRIs in their half-lives, clinical activity, side effects, and drug interactions.
Certain differences between SSRIs are clinically significant.
However, now its marketing status is "Discontinued".
Citalopram has been associated with loss of libido and may be associated with a relatively higher level of sexual dysfunction compared with sertraline.In due course, the levels of natural serotonin will rise again, and in some instances the SSRI can be reduced and withdrawn.SSRI antidepressants are at least 10-fold more selective for serotonin reuptake inhibition than for norepinephrine reuptake.Each antidepressant produces approximately a 60% overall response rate (ie, at least a 50% reduction in symptoms as a result of treatment).However, some differences in the SSRIs efficacy exist.
Escitalopram may be superior in efficacy compared with other SSRIs in the treatment of major depressive disorder While SSRIs do not appear to differ in overall tolerability, the reported incidences of specific side effects vary.